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US 2011/0238186 A1Published application
Preparation of regenerative tissue scaffolds
AssigneeLifeCell Corporation
InventorsRick Owens, Wendell Sun, Mike Liu, Yong Mao
Life of this patent
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Abstract
Devices and methods for treating or repairing a tissue or organ defect or injury are provided. The devices can include tissue scaffolds produced from acellular tissue matrices and polymers, which have a stable three-dimensional shape and elicit a limited immunologic or inflammatory response.
Claims56
A method for making a tissue scaffold, comprising:
- dissolving a polymer in a solvent to make a solution;
- mixing the solution with a particulate acellular tissue matrix (ATM) to create a mixture;
- placing the mixture in a mold;
- and
- drying the mixture to form a tissue scaffold with a stable three-dimensional shape, wherein the tissue scaffold has a reduced immunological or inflammatory response when implanted in a human than the polymer alone.
2 more elements
A tissue scaffold, comprising:
- a particulate acellular tissue matrix (ATM);
- and
- a polymer;
- wherein the ATM is encased in the polymer to form a stable three-dimensional tissue scaffold for tissue regeneration, and wherein the tissue scaffold has a reduced immunological or inflammatory response when implanted in a human than the polymer alone.
1 more element
A method of treatment, comprising:
- (a) selecting a tissue scaffold having a stable three-dimensional shape, the tissue scaffold comprising:
- (i) a particulate acellular tissue matrix (ATM);
- and
- (ii) a polymer;
- wherein the ATM is encased in the polymer to form a stable three-dimensional tissue scaffold for tissue regeneration, and wherein the tissue scaffold has a reduced immunological or inflammatory response when implanted in a human than the polymer alone;
- (b) identifying a defect in a tissue or organ;
- and
- (c) implanting the tissue scaffold in the defect.
5 more elements
Dependencies are inferred from the claim text.