Neural stimulation for treatment of metabolic syndrome and type 2 diabetes
AssigneeAdvanced Neuromodulation Systems, Inc.
InventorJohn D. Dobak, III
Life of this patent
Estimating the term…
Abstract
Systems and methods are described for treating metabolic syndrome and/or Type 2 diabetes, and/or one or more of their attendant conditions, by neural stimulation. In one embodiment, an implantable pulse generator is electrically coupled to a peripheral nerve, such as the splanchnic nerve. Neural stimulation configured to either block transmission or stimulate transmission of the peripheral nerve may be used to treat metabolic syndrome and Type 2 diabetes.
Claims16
A method of lowering blood pressure in a subject comprising:
- establishing a baseline blood pressure;
- electrically stimulating a sympathetic nerve with at least one stimulation pattern comprising more than one dose comprising at least one soft transition, at least one dose ramp or combinations thereof, wherein the electrical stimulation with the at least one stimulation pattern occurs for at least one week;
- establishing a post stimulation blood pressure, wherein the post stimulation blood pressure is lower than the baseline blood pressure.
A method of treating a subject having hypertension comprising:
- selecting a subject having hypertension;
- and
- electrically stimulating a sympathetic nerve with at least one stimulation pattern comprising more than one dose comprising at least one soft transition, at least one dose ramp or combinations thereof, wherein the electrical stimulation with the at least one stimulation pattern occurs for at least one week, wherein the hypertensive state of the patient is improved.
A method of improving the cardiovascular health of a subject comprising:
- selecting a subject that is exercise compromised;
- measuring an at least one cardiovascular metric;
- electrically stimulating a sympathetic nerve with at least one stimulation pattern comprising more than one dose comprising at least one soft transition, at least one dose ramp or combinations thereof, wherein the electrical stimulation with the at least one stimulation pattern occurs for at least one week;
- and
- measuring the at least one cardiovascular metric, wherein the cardiovascular metric is improved.
The method of claim 13 wherein the leading soft transition is less than 10 seconds and the ending soft transition is less than 10 seconds.
Dependencies are inferred from the claim text.