Drug delivery to a joint
AssigneeHospital for Special Surgery
InventorsRobert N. HOTCHKISS, John A. Koski
Life of this patent
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Abstract
A drug delivery device may include a base to be percutaneously affixable in an attachment zone of a synovial joint and a sustained-release drug carrier coupled to the base. The drug delivery device may also include an access device to provide access to the attachment zone. The attachment zone may comprise a non-articulating portion of a bone and/or cartilage with the synovial joint and the drug carrier may elute the drug into the synovial fluid sufficient to sustain a therapeutically effective concentration of the drug in the synovial fluid for at least 8 hours.
Claims36
A sustained-release intra-articular drug delivery device, comprising:
- a base, so sized and shaped as to be percutaneously affixable in an attachment zone of a synovial joint, the attachment zone comprising a non-articulating portion of bone and/or cartilage with the synovial joint;
- and
- a sustained-release drug carrier coupled to the base, the carrier including a drug, the carrier so formed as to elute the drug into synovial fluid, upon implantation of the device in a joint, sufficient to sustain a therapeutically effective concentration of the drug in the synovial fluid for at least 8 hours.
A sustained-release intra-articular drug delivery device, comprising:
- a base, so sized and shaped as to be percutaneously affixable in an attachment zone of a synovial joint, the attachment zone comprising a non-articulating portion of bone and/or cartilage with the synovial joint;
- a sustained-release drug carrier coupled to the base, the carrier including a drug, the carrier so formed as to elute the drug into synovial fluid, upon implantation of the device in a joint, sufficient to sustain a therapeutically effective concentration of the drug in the synovial fluid for at least 8 hours;
- and
- an access device, so sized and shaped as to provide access to the attachment zone.
Dependencies are inferred from the claim text.