Stabilized steroid composition and method for its preparation
AssigneePrecision Dermatology, Inc.
InventorPravin M. Patel
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Abstract
Stabilized, 17-substituted hydrocortisone containing compositions and methods of manufacture are disclosed. Isomerization of the hydrocortisone component of topical steroid compositions is markedly reduced by including an omega-6 acid component in the form of a free acid or as a compound such as an ester. Specifically disclosed are methods for preventing the isomerization of hydrocortisone 17-butyrate into hydrocortisone 21-butyrate through the use of safflower oil.
Claims16
A method for stabilizing a composition including a 17-substituted hydrocortisone therein, said method comprising the step of:
- adding a stabilizer to said composition, said stabilizer comprising an omega-6 acid or an ester of an omega-6 acid.
A method for stabilizing a 17-substituted hydrocortisone compound, said method comprising the step of
- disposing said hydrocortisone compound in a composition which includes a stabilizer comprising an omega-6 acid or an ester of an omega-6 acid.
A stabilized hydrocortisone composition comprising:
- a 17-substituted hydrocortisone;
- and
- a stabilizer comprising an omega-6 acid or an ester of an omega-6 acid.
A stabilized composition comprising:
- hydrocortisone 17-butyrate;
- and
- a stabilizer comprising an omega-6 acid or an ester of said omega-6 acid;
- wherein said stabilizer is present in an amount such that the molar concentration of the omega-6 acid component thereof is greater than the molar concentration of said hydrocortisone butyrate.
Dependencies are inferred from the claim text.