Spatially-defined macrocyclic compounds useful for drug discovery

A compound of formula W-T-X, wherein T is selected from the group consisting of

• wherein:
• W is selected from the group consisting of —OH, —NH2 and —NHR3, wherein R3 is lower alkyl and X is —NH2 or —NHR3, wherein R3 is lower alkyl, or X is —OH and W is —NHR3, wherein R3 is lower alkyl;
• Y is hydrogen, alkyl, benzyl or acyl;
• (W) indicates the point of attachment of T to W;
• and (X) indicates the point of attachment of T to X, and
• W, X and/or —OY may be optionally protected by one or more protecting groups.