Hydrazonopyrazole derivatives and their use as therapeutics

A compound of formula (Ia):

• wherein:
• n is 0 to 5;
• R3 and R4 are each independently —N(R7)2 or —N(R7)C(O)R6;
• R5 is aryl optionally substituted with one or more substituents selected from the group consisting of alkyl, halo, nitro, cyano, haloalkyl, haloalkoxy, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, —OR6, —R8—OR6, —R8—[O—R8]m—OR6 (where m is 1 to 4), —S(O)2OH, —S(O)tR7 (where t is 0 to 2), —S(O)t—R8—OR6—, —S(O)t—N(R6)2, —R8—P(O)(OR9)2, —C(O)OR6, —R8—C(O)OR6, —C(O)N(R6)2, —N(R7)2, —R8—N(R7)2, and —N(R9)C(O)R6;
• or R5 is heterocyclyl optionally substituted with one or more substituents selected from the group consisting of alkyl, halo, nitro, cyano, haloalkyl, haloalkoxy, aryl, heterocyclyl, heterocyclylalkyl, —OR6, —R8—OR6, —R8—[OR8]m—OR6 (where m is 1 to 4), —S(O)2OH, —S(O)tR7 (where t is 0 to 2), —S(O)t—R8—OR6, —S(Ot—N(R6)2, —R8—P(O)(OR9)2, —C(O)OR6, —R8—C(O)OR6, —C(O)N(R6)2, —N(R7)2, —R8—N(R7)2, and —N(R9)C(O)R6;
• each R6 is independently hydrogen, alkyl, aryl, aralkyl, heterocyclyl or heterocyclylalkyl;
• each R7 is independently hydrogen, alkyl, haloalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, or —R8—OR9;
• each R8 is a straight or branched alkylene chain;
• and
• each R9 is hydrogen or alkyl;
• provided that when n is 0, and R3 and R4 are both —NH2, R5 can not be phenyl, naphth-2-yl, pyridin-3-yl, 3-methoxyphenyl, 3-chlorophenyl, 4-bromophenyl, 2-methylphenyl, 2-chlorophenol, 3-nitrophenyl, 4-aminosulfonylphenyl, or 4-(pyrimidin-2-yl)aminosulfonylphenyl;
• as a single stereoisomer, a mixture of stereoisomers, a solvate or a polymorph;
• or a pharmaceutically acceptable salt thereof.