Methods and systems for generating nanoparticles
AssigneeCerulean Pharma Inc.
InventorsJohn Podobinski, J. Michael Ramstack, David S. Dickey
Life of this patent
Estimating the term…
Abstract
In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent stream.
Claims136
A process for forming polymeric nanoparticles, comprising:
- introducing an anti-solvent into a static mixer to create a mixed flowing stream of the anti-solvent,
- introducing a polymer solution into said mixed flowing stream of the anti-solvent such that controlled precipitation of polymeric nanoparticles occurs.
A process for forming polymeric nanoparticles, comprising:
- introducing an anti-solvent into a static mixer so as to generate a mixed flowing stream of said anti-solvent,
- introducing a polymer solution into said mixed flowing stream of said anti-solvent to generate polymeric nanoparticles via precipitation such that said polymeric nanoparticles exhibit a polydispersity index less than about 0.25.
A process for controlling particle size of nanoparticles formed by precipitation, comprising:
- introducing an anti-solvent liquid flow into a static mixer to generate a mixed flowing stream of the anti-solvent,
- introducing a polymer solution into said mixed flowing stream of the anti-solvent so as to generate a plurality of polymeric nanoparticles by precipitation, and
- controlling a flow rate of said mixed flowing stream of the anti-solvent through said static mixer so as to adjust an average particle size of said nanoparticles.
A system for generating polymeric nanoparticles, comprising
- a conduit having a first input port for receiving an anti-solvent,
- a static mixer disposed in said conduit to generate a mixed flowing stream of said anti-solvent, said static mixer extending from a proximal end to a distal end,
- said conduit having a second input port disposed relative to the static mixer so as to allow introducing a polymer solution into said mixed flowing stream of the anti-solvent to generate polymeric nanoparticles via precipitation, and
- a device adapted to cause a flow of said anti-solvent from a reservoir to said conduit and to control a flow rate of said anti-solvent through said static mixer for adjusting an average particle size of said nanoparticles.
A device for generating nanoparticles, comprising
- a conduit having a first input port for receiving a stream of a liquid anti-solvent and an output port,
- a static mixer disposed in said conduit to cause mixing of the anti-solvent stream to generate a mixed flowing stream of the anti-solvent, said static mixer extending from a proximal end to a distal end,
- said conduit having a second input port positioned relative to said static mixer so as to allow delivery of a polymer solution into said mixed flowing stream of the anti-solvent for generating polymeric nanoparticles by precipitation.
A device for generating nanoparticles, comprising
- a conduit having a first input port for receiving a stream of a liquid anti-solvent and an output port,
- a static mixer disposed in said conduit to cause mixing of the anti-solvent stream to generate a mixed flowing stream of the anti-solvent, said static mixer extending from a proximal end to a distal end, and
- an injector coupled to said conduit for injecting a polymer solution into said mixed flowing stream of the anti-solvent.
Dependencies are inferred from the claim text.