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US 2011/0237679 A1Published application
Novel antiviral compounds, compositions, and methods of use
AssigneeCytokine PharmaSciences, Inc.
InventorThais M. Sielecki-Dzurdz
Life of this patent
Estimating the term…
Abstract
Compounds, salts thereof, and tautomers thereof are disclosed. Compositions that include the compounds are disclosed. Methods of making and using the compounds are also disclosed.
Claims42
A compound having one of the following formulas:
- or salt thereof;
- or tautomer thereof;
- wherein each is independently a single bond or a double bond;
- wherein when, in one or both of rings A and B, all of are double bonds, the respective A or B ring may form a resonance structure;
- wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, and X10 are each independently selected from the group consisting of —CR3═, —CR3R4—, —NR4—, —N═, and —O—;
- wherein R1 is selected from the group consisting of hydrogen, hydroxyl, —OR5, —NR5R6, —C(NR5)R6, —C(NR5)OR6, —NO2, —NH2, —CONR5R6, —COR5, —COOR5, —SO2R5, —C(COR5)R6, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, and salt thereof;
- wherein R2 is selected from the group consisting of hydrogen, —R5OR6, —COOR5, —COR5, —PO3R5R6, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, and salt thereof;
- wherein R3 and R4 are each independently hydrogen, hydroxyl, halo, bromo, chloro, iodo, fluoro, —OR5, —NR5R6, —NR5COR6, —CONR5R6, —CONR5, —COOR5, —OCOR5, —COR5, —SR5, —SO2R5, —SO3R5, —SO2NR5, —SOR5, —N3, —CN, —NC, —SH, —NO2, —NH2, —PR2, —(O)PR5R6, —PO3R5R6, —OPO3R5R6, —PO2, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, or perhalo(C1-C20)alkyl, or, when R3 and R4 are taken together on a single X, may form an ═O group or a ═CR3R4 group, or, when R3 and R4 are taken together with adjacent Xs, may form a (C3-C6)cycloalkyl structure, a (C5-C6)aryl structure, a (C3-C6)heteroaryl structure, a (C3-C6)heterocyclyl structure, a (C3-C6)heterocycloalkenyl structure, or a (C4-C6)cycloalkenyl structure, or salt thereof;
- wherein R5 and R6 are each independently selected from the group consisting of hydrogen, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, and salt thereof;
- and wherein each of said (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, (C3-C6)cycloalkyl structure, (C5-C6)aryl structure, (C3-C6)heteroaryl structure, (C3-C6)heterocyclyl structure, a (C3-C6)heterocycloalkenyl structure, or (C4-C6)cycloalkenyl structure may be independently unsubstituted or substituted by one or more substituents selected from the group consisting of hydroxyl, halo, bromo, chloro, iodo, fluoro, —OR5, —NR5R6, —NR5COR6, —CONR5R6, —CONR5, —COOR5, —OCOR5, —COR5, —SR5, —SO2R5, —SO3R5, —SO2NR5, —SOR5, —N3, —CN, —NC, —SH, —NO2, —NH2, —PR2, —(O)PR5R6, —PO3R5R6, —OPO3R5R6, —PO2, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, salt thereof, and a combination thereof;
- with the provisos that:
- Rule (1) when N′ is αN′— and R1 and R2 are H, and the B ring is
- then the A ring is not:
- Rule (2) when N′ is ═N′—, R2 is H, R1 is —CH4, and the B ring is
- then the A ring is not:
- Rule (3) when N′ is ═N′—, when R1 and R2 are H, and when the A ring is
- then the B ring is not
- Rule (4) when N′ is ═N′—, when R1 and R2 are both H, and the B ring is
- then the A ring is not:
- Rule (5) when N′ is ═N′—, when R1 and R2 are both H, and the A ring is
- then the B ring is not
- Rule (6) when R1 is ethyl, R2 is H, when N′ is ═N′— and the A ring is
- then the B ring is not
- Rule (7) when R1 is H, R2 is H, when N′ is ═N′—, and when A ring is
- then the B ring is not
- Rule (8) when R1 and R2 are H, when N′ is ═N′—, and when B ring is
- then the A ring is not
24 more elements
A composition, comprising at least two different compounds having one of the following formulas:
- or salt thereof;
- or tautomer thereof;
- wherein each is independently a single bond or a double bond;
- wherein when, in one or both of rings A and B, all of are double bonds, the respective A or B ring may form a resonance structure;
- wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, and X10 are each independently selected from the group consisting of —CR3═, —CR3R4—, —NR4—, —N═, and —O—;
- wherein R1 is selected from the group consisting of hydrogen, hydroxyl, —OR5, —NR5R6, —C(NR5)R6, —C(NR5)OR6, —NO2, —NH2, —CONR5R6, —COR5, —COOR5, —SO2R5, —C(COR5)R6, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, and salt thereof;
- wherein R2 is selected from the group consisting of hydrogen, —R5OR6, —COOR5, —COR5, —PO3R5R6, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, and salt thereof;
- wherein R3 and R4 are each independently hydrogen, hydroxyl, halo, bromo, chloro, iodo, fluoro, —OR5, —NR5R6, —NR5COR6, —CONR5R6, —CONR5, —COOR5, —OCOR5, —COR5, —SR5, —SO2R5, —SO3R5, —SO2NR5, —SOR5, —N3, —CN, —NC, —SH, —NO2, —NH2, —PR2, —(O)PR5R6, —PO3R5R6, —OPO3R5R6, —PO2, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, or perhalo(C1-C20)alkyl, or, when R3 and R4 are taken together on a single X, may form an ═O group or a ═CR3R4 group, or, when R3 and R4 are taken together with adjacent Xs, may form a (C3-C6)cycloalkyl structure, a (C5-C6)aryl structure, a (C3-C6)heteroaryl structure, a (C3-C6)heterocyclyl structure, a (C3-C6)heterocycloalkenyl structure, or a (C4-C6)cycloalkenyl structure, or salt thereof;
- wherein R5 and R6 are each independently selected from the group consisting of hydrogen, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, and salt thereof;
- and wherein each of said (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, (C3-C6)cycloalkyl structure, (C5-C6)aryl structure, (C3-C6)heteroaryl structure, (C3-C6)heterocyclyl structure, a (C3-C6)heterocycloalkenyl structure, or (C4-C6)cycloalkenyl structure may be independently unsubstituted or substituted by one or more substituents selected from the group consisting of hydroxyl, halo, bromo, chloro, iodo, fluoro, —OR5, —NR5R6, —NR5COR6, —CONR5R6, —CONR5, —COOR5, —OCOR5, —COR5, —SR5, —SO2R5, —SO3R5, —SO2NR5, —SOR5, —N3, —CN, —NC, —SH, —NO2, —NH2, —PR2, —(O)PR5R6, —PO3R5R6, —OPO3R5R6, —PO2, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, salt thereof, and a combination thereof.
7 more elements
A composition, comprising at least one pharmaceutically acceptable carrier and at least one compound having one of the following formulas:
- or salt thereof;
- or tautomer thereof;
- wherein each is independently a single bond or a double bond;
- wherein when, in one or both of rings A and B, all of are double bonds, the respective A or B ring may form a resonance structure;
- wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, and X10 are each independently selected from the group consisting of —CR3═, —CR3R4—, —NR4—, —N═, and —O—;
- wherein R1 is selected from the group consisting of hydrogen, hydroxyl, —OR5, —NR5R6, —C(NR5)R6, —C(NR5)OR6, —NO2, —NH2, —CONR5R6, —COR5, —COOR5, —SO2R5, —C(COR5)R6, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, and salt thereof;
- wherein R2 is selected from the group consisting of hydrogen, —R5OR6, —COOR5, —COR5, —PO3R5R6, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, and salt thereof;
- wherein R3 and R4 are each independently hydrogen, hydroxyl, halo, bromo, chloro, iodo, fluoro, —OR5, —NR5R6, —NR5COR6, —CONR5R6, —CONR5, —COOR5, —OCOR5, —COR5, —SR5, —SO2R5, —SO3R5, —SO2NR5, —SOR5, —N3, —CN, —NC, —SH, —NO2, —NH2, —PR2, —(O)PR5R6, —PO3R5R6, —OPO3R5R6, —PO2, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C2)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, or perhalo(C1-C20)alkyl, or, when R3 and R4 are taken together on a single X, may form an ═O group or a ═CR3R4 group, or, when R3 and R4 are taken together with adjacent Xs, may form a (C3-C6)cycloalkyl structure, a (C5-C6)aryl structure, a (C3-C6)heteroaryl structure, a (C3-C6)heterocyclyl structure, a (C3-C6)heterocycloalkenyl structure, or a (C4-C6)cycloalkenyl structure, or salt thereof;
- wherein R5 and R6 are each independently selected from the group consisting of hydrogen, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, and salt thereof;
- and wherein each of said (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, (C3-C6)cycloalkyl structure, (C5-C6)aryl structure, (C3-C6)heteroaryl structure, (C3-C6)heterocyclyl structure, a (C3-C6)heterocycloalkenyl structure, or (C4-C6)cycloalkenyl structure may be independently unsubstituted or substituted by one or more substituents selected from the group consisting of hydroxyl, halo, bromo, chloro, iodo, fluoro, —OR5, —NR5R6, —NR5COR6, —CONR5R6, —CONR5, —COOR5, —OCOR5, —COR5, —SR5, —SO2R5, —SO3R5, —SO2NR5, —SOR5, —N3, —CN, —NC, —SH, —NO2, —NH2, —PR2, —(O)PR5R6, —PO3R5R6, —OPO3R5R6, —PO2, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, salt thereof, and a combination thereof.
7 more elements
A composition, comprising:
- at least one inhibitor selected from the group consisting of Nucleoside analog Reverse Transcriptase inhibitor (NRTi), Non-Nucleoside analog Reverse Transcriptase inhibitor (NNRTi), Protease inhibitor (Pi), Cell Entry inhibitor (Ci), and a combination thereof;
- and
- at least one compound having one of the following formulas:
- or salt thereof;
- or tautomer thereof;
- wherein each is independently a single bond or a double bond;
- wherein when, in one or both of rings A and B, all of are double bonds, the respective A or B ring may form a resonance structure;
- wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, and X10 are each independently selected from the group consisting of —CR3═, —CR3R4—, —NR4—, —N═, and —O—;
- wherein R1 is selected from the group consisting of hydrogen, hydroxyl, —OR5, —NR5R6, —C(NR5)R6, —C(NR5)OR6, —NO2, —NH2, —CONR5R6, —COR5, —COOR5, —SO2R5, —C(COR5)R6, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, and salt thereof;
- wherein R2 is selected from the group consisting of hydrogen, —R5OR6, —COOR5, —COR5, —PO3R5R6, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, and salt thereof;
- wherein R3 and R4 are each independently hydrogen, hydroxyl, halo, bromo, chloro, iodo, fluoro, —OR5, —NR5R6, —NR5COR6, —CONR5R6, —CONR5, —COOR5, —OCOR5, —COR5, —SR5, —SO2R5, —SO3R5, —SO2NR5, —SOR5, —N3, —CN, —NC, —SH, —NO2, —NH2, —PR2, —(O)PR5R6, —PO3R5R6, —OPO3R5R6, —PO2, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, or perhalo(C1-C20)alkyl, or, when R3 and R4 are taken together on a single X, may form an ═O group or a ═CR3R4 group, or, when R3 and R4 are taken together with adjacent Xs, may form a (C3-C6)cycloalkyl structure, a (C5-C6)aryl structure, a (C3-C6)heteroaryl structure, a (C3-C6)heterocyclyl structure, a (C3-C6)heterocycloalkenyl structure, or a (C4-C6)cycloalkenyl structure, or salt thereof;
- wherein R5 and R6 are each independently selected from the group consisting of hydrogen, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, and salt thereof;
- and wherein each of said (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, (C3-C6)cycloalkyl structure, (C5-C6)aryl structure, (C3-C6)heteroaryl structure, (C3-C6)heterocyclyl structure, a (C3-C6)heterocycloalkenyl structure, or (C4-C6)cycloalkenyl structure may be independently unsubstituted or substituted by one or more substituents selected from the group consisting of hydroxyl, halo, bromo, chloro, iodo, fluoro, —OR5, —NR5R6, —NR5COR6, —CONR5R6, —CONR5, —COOR5, —OCOR5, —COR5, —SR5, —SO2R5, —SO3R5, —SO2NR5, —SOR5, —N3, —CN, —NC, —SH, —NO2, —NH2, —PR2, —(O)PR5R6, —PO3R5R6, —OPO3R5R6, —PO2, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, salt thereof, and a combination thereof.
10 more elements
A method for treating a known or suspected malady, in an animal, selected from the group consisting of HIV infection, hepatitis C, hepatitis B, hepatitis delta, influenza, herpes, adenovirus, papillomavirus, parvovirus, measles, bird flu, and a combination thereof, comprising administering, to the animal, at least one compound having one of the following formulas:
- or salt thereof;
- or tautomer thereof;
- wherein each is independently a single bond or a double bond;
- wherein when, in one or both of rings A and B, all of are double bonds, the respective A or B ring may form a resonance structure;
- wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, and X10 are each independently selected from the group consisting of —CR3═, —CR3R4—, —NR4—, —N═, and —O—;
- wherein R1 is selected from the group consisting of hydrogen, hydroxyl, —OR5, —NR5R6, —C(NR5)R6, —C(NR5)OR6, —NO2, —NH2, —CONR5R6, —COR5, —COOR5, —SO2R5, —C(COR5)R6, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, and salt thereof;
- wherein R2 is selected from the group consisting of hydrogen, —R5OR6, —COOR5, —COR5, —PO3R5R6, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, and salt thereof;
- wherein R3 and R4 are each independently hydrogen, hydroxyl, halo, bromo, chloro, iodo, fluoro, —OR5, —NR5R6, —NR5COR6, —CONR5R6, —CONR5, —COOR5, —OCOR5, —COR5, —SR5, —SO2R5, —SO3R5, —SO2NR5, —SOR5, —N3, —CN, —NC, —SH, —NO2, —NH2, —PR2, —(O)PR5R6, —PO3R5R6, —OPO3R5R6, —PO2, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, or perhalo(C1-C20)alkyl, or, when R3 and R4 are taken together on a single X, may form an ═O group or a ═CR3R4 group, or, when R3 and R4 are taken together with adjacent Xs, may form a (C3-C6)cycloalkyl structure, a (C5-C6)aryl structure, a (C3-C6)heteroaryl structure, a (C3-C6)heterocyclyl structure, a (C3-C6)heterocycloalkenyl structure, or a (C4-C6)cycloalkenyl structure, or salt thereof;
- wherein R5 and R6 are each independently selected from the group consisting of hydrogen, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, and salt thereof;
- and wherein each of said (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, (C3-C6)cycloalkyl structure, (C5-C6)aryl structure, (C3-C6)heteroaryl structure, (C3-C6)heterocyclyl structure, a (C3-C6)heterocycloalkenyl structure, or (C4-C6)cycloalkenyl structure may be independently unsubstituted or substituted by one or more substituents selected from the group consisting of hydroxyl, halo, bromo, chloro, iodo, fluoro, —OR5, —NR5R6, —NR5COR6, —CONR5R6, —CONR5, —COOR5, —OCOR5, —COR5, —SR5, —SO2R5, —SO3R5, —SO2NR5, —SOR5, —N3, —CN, —NC, —SH, —NO2, —NH2, —PR2, —(O)PR5R6, —PO3R5R6, —OPO3R5R6, —PO2, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclyl, (C2-C20)alkenyl, (C4-C20)cycloalkenyl, (C2-C20)alkynyl, (C6-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, salt thereof, and a combination thereof.
7 more elements
Dependencies are inferred from the claim text.