Chromenone derivatives as trpv3 antagonists
AssigneeGlenmark Pharmaceuticals S.A.
InventorsSachin Sundarlal Chaudhari, Abraham Thomas, Ashok Bhausaheb Kadam, Sachin Vasantrao Dhone, Bharat Gangadhar Adik, Neelima Khairatkar-joshi, Vidya Ganapati Kattige
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Abstract
The present invention provides transient receptor potential vanilloid (TRPV) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.
Claims27
-29. (canceled)
A compound of the formula (I):
- wherein,
- at each occurrence, R1 is independently selected from nitro, cyano, halogen, —ORa, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic group, —NR4R5, —S(O)pNR4R5, and —S(O)pR4;
- R2 is selected from halogen, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heterocyclic group;
- wherein substituent(s) are independently selected from halogen, nitro, cyano, —NR4R5, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkoxy, substituted or unsubstituted haloalkyl, substituted or unsubstituted haloalkyloxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclic group, and substituted or unsubstituted heteroaryl;
- at each occurrence, R3 may be same or different and is selected from nitro, cyano, halogen, —ORa, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted cyanoalkyl, substituted or unsubstituted cyanoalkyloxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclic group, and substituted or unsubstituted heteroaryl;
- at each occurrence, Ra is independently selected from hydrogen, substituted or unsubstituted alkyl, linear or branched chain alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted cyanoalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkoxyalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic group, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroarylalkyl, and substituted or unsubstituted heterocyclylalkyl;
- at each occurrence, R4 and R5 are independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted heterocyclic group, and substituted or unsubstituted heterocyclylalkyl;
- ‘n’ is an integer selected from 0 to 5, both inclusive;
- ‘m’ is an integer selected from 0 to 4, both inclusive;
- and
- at each occurrence, ‘p’ is an integer selected from 0 to 2, both inclusive;
- or pharmaceutically acceptable salt there of.
The compound of claim 2, wherein Rb is methyl.
Dependencies are inferred from the claim text.