Compound and method for the treatment of pain
AssigneeKrishani Biosciences (P) Ltd
InventorMAHESH KANDULA
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Abstract
The disclosure herein provides a compound of formula 1. The disclosure also provides a method of synthesizing the compound of formula 1. The compound of formula 1 or its pharmaceutical acceptable salts, as well as polymorphs, solvates, and hydrates thereof may be formulated as pharmaceutical composition. The pharmaceutical composition of compound of formula 1 or the final compound may be formulated for non-invasive peroral, topical (example transdermal), enteral, transmucosal, targeted delivery, sustained release delivery, delayed release, pulsed release and parenteral methods. Such compositions may be used to treat chronic pain manifested with chronic diseases or its associated complications.
Claims18
A compound, comprising:
- a compound of formula 1:
- wherein R1, R2, R3 and R4 are at least one of hydrogen, methyl, amine, cyclohexyl methyl ether, butoxy, propoxy, halogen (chlorine, flourine), thiol, alkyl, alkyl thiol, acetyl thiol, disulfide, acyl, acylalkyl, alkenyl, alkylthioalkyl, alkynyl, alkoxyaryl, alkoxyalkyl, aryl, aralkyl, aryloxyalkyl, arylthioalkyl, cycloalkyl, ether, ester, heteroaryl, heterocyclyl, lower alkyl, sulfone, sulfoxide and hydroxyalkyl;
- R5 represents at least one of a hydrogen, carboxyl, amine, —NH—CO—NH—, —NH—CO—CH2—NH—,
- and an analog of any one of the foregoing;
- wherein n represents an integer from 0 to 11;
- R6 represents at least one of a hydrogen, amine, —NH—CO—, R—COO—R1, thiol, disulfide and
- and
- R7 represents at least one of a 6,8-dithiooctanoic acid,
A method, comprising;
- synthesizing a compound of formula 1, further comprising:
- stirring a reaction mixture of ethyl methyl ketone and paraformaldehyde at 40° C.;
- slowly adding NaOH until the reaction mixture turns blue;
- neutralizing the reaction mixture by adding glacial acetic acid;
- separating and washing an organic layer with brine;
- drying the organic layer over anhydrous Na2SO4,
- evaporating the organic layer under reduced pressure to form a dried product;
- and
- purifying the dried product by high vacuum distillation under reduced pressure to yield an intermediate compound 2.
A method of treating, comprising;
- administering the compound of formula 1, comprising:
- wherein, R1, R2, R3 and R4 each independently may represent hydrogen, methyl, amine, cyclohexyl methyl ether, butoxy, propoxy, halogen (Chlorine or Flourine), thiol, alkyl, alkyl thiol, acetyl thiol, disulfide, acyl, acylalkyl, alkenyl, alkylthioalkyl, alkynyl, alkoxyaryl, alkoxyalkyl, aryl, aralkyl, aryloxyalkyl, arylthioalkyl, cycloalkyl, ether, ester, heteroaryl, heterocyclyl, lower alkyl, sulfone, sulfoxide, or hydroxyalkyl;
- R5 independently represents hydrogen, carboxyl, amine, —NH—CO—NH—, —NH—CO—CH2—NH—,
- or an analog of any of the foregoing;
- where, n represents an integer from 0 to 11.
- R6 independently represents hydrogen, amine, —NH—CO—, R—COO—R1, thiol, disulfide, or
- R7 independently represents at least one of a 6,8-dithiooctanoic acid,
Dependencies are inferred from the claim text.