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US 2011/0237644 A1Published application
Ubiquitin specific proteases responsible for mcl-1 stability and uses thereof
AssigneesLes Laboratoires Servier, Hybrigenics
InventorsOlivier Geneste, John Hickman, Frédéric Colland, Laurent Daviet
Life of this patent
Estimating the term…
Abstract
Use of a polypeptide selected from the group consisting of USP13, USP26, USP38, USP42 or USP46 as a screening tool for an agent for treating cancer.
Claims10
1-9. (canceled)
A screening tool to identify an agent for treating cancer, comprising a Ubiquitin Specific Protease (USP) polypeptide selected from a) USP13, USP26, USP38, USP42, USP46;
- b) a functional fragment of a polypeptide USP13, USP26, USP38, USP42 or USP46 and exhibiting an activity of deubiquitination;
- and c) a polypeptide comprising an amino acid sequence having a 84% or more homology with a polypeptide consisting of USP13, USP26, USP38, USP42 or USP46 and exhibiting an activity of deubiquitination.
Dependencies are inferred from the claim text.