Process for Forming Amorphous Atorvastatin
AssigneePfizer Inc.
InventorsAntone J. deBettencourt, III, Peter R. Rose, Evgenyi Shalaev, George J. Quallich, Carl B. Ziegler, JR.
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Abstract
A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solutilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.
Claims15
A process for forming amorphous atorvastatin comprising:
- (a) dissolving atorvastatin and optionally an excipient in a non-hydroxylic solvent to form a solution;
- and
- (b) lyophilizing the solution to afford amorphous atorvastatin.
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A process for forming amorphous atorvastatin comprising:
- (a) dissolving atorvastatin in a hydroxylic solvent containing an alkalizing agent;
- and
- (b) lyophilizing the solution to afford said amorphous atorvastatin.
The process for forming amorphous atorvastatin comprising:
- (a) dissolving atorvastatin and an antioxidant in a hydroxylic solvent;
- and
- (b) lyophilizing the solution to afford said amorphous atorvastatin.
Dependencies are inferred from the claim text.