Tetrahydronaphthalene derivatives
AssigneeConcert Pharmaceuticals, Inc.
InventorsRoger Tung, Craig E. Masse
Life of this patent
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Abstract
This invention relates to novel tetrahydronaphthalene derivatives, and pharmaceutically acceptable salts thereof according to the following formulae, in one embodiment: as described herein. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a selective T-type calcium channel blocker.
Claims33
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- Ra, Rb and Rc are each independently selected from —CH3, —CDH2, —CD2H, and —CD3;
- Y1a and Y1b are each independently selected from hydrogen, deuterium, and fluorine;
- Y2a and Y2b are each independently selected from hydrogen and deuterium;
- Y3a and Y3b are each independently selected from hydrogen and deuterium;
- Y4a and Y4b are each independently selected from hydrogen and deuterium;
- and
- R1 is selected from —CH3, —CDH2, —CD2H, and —CD3;
- provided that when each of Y1a, Y1b, Y2a, Y2b, Y3a, Y3b, Y4a, and Y4b is hydrogen, R1 comprises at least one deuterium.
A compound of Formula A
- or a pharmaceutically acceptable salt thereof, wherein:
- Ra, Rb and Rc are each independently selected from —CH3, —CDH2, —CD2H, and —CD3;
- Y1a and Y1b are each independently selected from hydrogen, deuterium and fluorine;
- Y2a and Y2b are each independently selected from hydrogen and deuterium;
- Y3a and Y3b are each independently selected from hydrogen and deuterium;
- Y4a and Y4b are each independently selected from hydrogen and deuterium;
- Y5a and Y5b are each independently selected from hydrogen and deuterium;
- Y6a and Y6b are each independently selected from hydrogen and deuterium;
- Y7a and Y7b are each independently selected from hydrogen and deuterium;
- Y8 is selected from hydrogen and deuterium;
- Y9 is selected from hydrogen and deuterium;
- and
- R1 is selected from —CH3, —CDH2, —CD2H, and —CD3;
- provided that when each of Y1a, Y1b, Y1a, Y2b, Y3a, Y3b, Y4a, Y4b, Y5a, Y5b, Y6a, Y6b, Y7a, Y7b, Y8 and Y9 is hydrogen, R1 comprises at least one deuterium.
A compound of Formula C
- or a pharmaceutically acceptable salt thereof, wherein
- Rd and Re are each independently hydrogen or deuterium;
- or Rd and Re taken together with the carbon to which they are connected form a 3-membered carbocyclic ring that is optionally substituted with deuterium;
- provided that if Rd and Rc are each independently hydrogen or deuterium, then Rf is ORc wherein Rc is selected from —CH3 and —CD3;
- and provided that if Rd and Re taken together with the carbon to which they are connected form a 3-membered carbocyclic ring, then Rf is hydrogen or deuterium;
- Y3a and Y3b are each independently selected from hydrogen and deuterium;
- Y5a and Y5b are each independently selected from hydrogen and deuterium;
- Y8 is selected from hydrogen and deuterium;
- Y9 is selected from hydrogen and deuterium;
- R1 is selected from —CH3 and —CD3;
- and
- each of Y2a, Y2b, Y6a, Y6b, Y7a and Y7b is the same and is either hydrogen or deuterium.
The compound of Formula C, wherein the compound is selected from any one of the compounds set forth in the table below, or a pharmaceutically acceptable salt thereof, wherein Y8, Y9 are each hydrogen;
- Ra and Rb are each —CH3, and each of Y3a, Y3b, Y5a, and Y5b is hydrogen, and wherein any atom not designated as deuterium is present at its natural isotopic abundance:
- Cmpd #
- R1
- Each of Y2a, Y2b, Y6a, Y6b, Y7a and Y7b
- 701a
- CH3
- D
- CH2OCH3
- 702a
- CD3
- H
- CH2OCH3
- 703a
- CD3
- D
- CH2OCH3
The compound of Formula C, wherein the compound is selected from any one of the compounds set forth in the table below, or a pharmaceutically acceptable salt thereof, wherein Y8, Y9 are each hydrogen;
- Ra and Rb are each —CH3, and each of Y3a, Y3b, Y5a, and Y5b is deuterium, and wherein any atom not designated as deuterium is present at its natural isotopic abundance:
- Cmpd #
- R1
- Each of Y2a, Y2b, Y6a, Y6b, Y7a and Y7b
- 700b
- CH3
- H
- CH2OCH3
- 701b
- CH3
- D
- CH2OCH3
- 702b
- CD3
- H
- CH2OCH3
- 703b
- CD3
- D
- CH2OCH3
Dependencies are inferred from the claim text.