Small molecule modulators of hepatocyte growth factor (scatter factor) activity

A pharmaceutical composition comprising a compound for modulating HGF/c-Met activity having the structure (I):

• or a geometrical isomer, tautomer, salt or hydrate thereof;
• wherein at least one A is N;
• wherein each occurrence of A is independently C or N;
• wherein Ar is a 6-10 membered aryl group or a 5-10 membered heteroaryl group;
• R1 is H, R5, COR4 or SO2R4;
• R2 is one or more H, hydroxy, halogen, cyano, OR4, nitro, NH2, NR4R4, NR4COR4, NR4SO2R4, CONR4R4, COOR4, SO2R4, ethynyl, optionally substituted aliphatic, alicyclic, heteroaliphatic, heterocyclic, aromatic, or heteroaromatic;
• R3 is one or more H, hydroxy, halogen, cyano, OR4, nitro, NH2, NR4R4, NR4COR4, NR4SO2R4, CONR4R4, COOR4, SO2R4, ethynyl, optionally substituted aliphatic, alicyclic, heteroaliphatic, heterocyclic, aromatic, or heteroaromatic;
• each occurrence of R4 is independently H, hydroxy, OR5, NH2, NR5R5, NR5COR5, NR5SO2R5, CONR5R5, or optionally substituted aliphatic, alicyclic, heteroaliphatic, heterocyclic, aromatic, or heteroaromatic;
• and
• each occurrence of R5 is independently H, hydroxy, or an optionally substituted aliphatic, alicyclic, heteroaliphatic, heterocyclic, aromatic, or heteroaromatic;
• and a pharmaceutically acceptable carrier, excipient or diluent;
• with the proviso that a compound having the following structure is excluded
• wherein Ar, R1, R2 and R3 are same as described above.