Carboxylic acid derivative containing thiazole ring and pharmaceutical use thereof
AssigneeMitsubishi Tanabe Pharma Corporation
InventorNaoko Ando
Life of this patent
Estimating the term…
Abstract
A compound represented by the formula (I) wherein R1 and R2 are each a hydrogen atom, an alkyl group and the like, R3 is a hydrogen atom, an alkyl group and the like, R4 is a hydrogen atom, an alkyl group and the like, m is an integer of 0 to 3, X is a bond, an oxygen atom or a sulfur atom, Y is a carbonyl group, a hydroxymethylene group and the like, and Z is a halogen atom, an alkyl group, an aryl group, a heteroaryl group and the like, or a pharmaceutically acceptable salt thereof has a superior PPARα agonist action and a lipid-lowering action, and is useful as a prophylactic or therapeutic drug for hyperlipidemia and the like.
Claims11
A carboxylic acid derivative containing a thiazole ring represented by the following formula (I)
- wherein
- R1 and R2 are the same or different and each is a hydrogen atom or an alkyl group optionally having substituent(s), or R1 and R2 are bonded to each other to form a cycloalkyl group optionally having substituent(s);
- R3 is a hydrogen atom or an alkyl group optionally having substituent(s);
- R4 is a hydrogen atom, an alkyl group optionally having substituent(s) or an aryl group optionally having substituent(s);
- m is an integer of 0 to 3;
- X is a bond, an oxygen atom or a sulfur atom;
- Y is a carbonyl group or a group represented by —CH(OR5)— wherein R5 is a hydrogen atom or an alkyl group optionally having substituent(s);
- and
- Z is
- a halogen atom,
- an alkyl group optionally having substituent(s),
- a cycloalkyl group optionally having substituent(s),
- an aryl group optionally having substituent(s),
- an arylalkyl group optionally having substituent(s),
- an arylalkenyl group optionally having substituent(s),
- an aryloxyalkyl group optionally having substituent(s),
- a heteroaryl group optionally having substituent(s) or
- a heteroarylalkyl group optionally having substituent(s), or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof.
A carboxylic acid which is 2-[(4-{[(4′-fluorobiphenyl-4-yl)oxy]acetyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid;
- 2-[(4-{2-[(4′-fluorobiphenyl-4-yl)oxy]-1-hydroxyethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid;
- 2-[(4-{[(4′-chlorobiphenyl-4-yl)oxy]acetyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid;
- 2-[(4-{2-[(4′-chlorobiphenyl-4-yl)oxy]-1-hydroxyethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid;
- 2-[(4-{2-[(4′-fluorobiphenyl-4-yl)oxy]-1-methoxyethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid;
- 2-{[4-(2-{[5-(4-fluorophenyl)pyridin-2-yl]oxy}-1-hydroxyethyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid;
- 2-[(4-{(1S)-2-[(4′-fluorobiphenyl-4-yl)oxy]-1-hydroxyethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid;
- or
- 2-[(4-{(1R)-2-[(4′-fluorobiphenyl-4-yl)oxy]-1-hydroxyethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid;
- or a derivative thereof or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof.
Dependencies are inferred from the claim text.