Heterocyclic compound and use thereof
AssigneeTakeda Pharmaceutical Company Limited
InventorMasanori Okaniwa
Life of this patent
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Abstract
A compound represented by formula (I) or a salt thereof, which has a potent Raf inhibitory activity. In formula (I), R1 represents an optionally substituted C1-6 alkyl, etc.; X represents —O— or —NR2— (wherein R2 represents a hydrogen atom or a C1-6 alkyl); Y represents a group represented by formula 2 (2ii or 2ii) (wherein ring A represents an optionally substituted benzene ring; Z represents a group represented by (1) —NR3CO—W1—, (2) —NR3CO—W1—O—, (3) —NR3CO—W1—O—W2—, (4) —NR3CO—W1—S—, (5) —NR3CO—W1—NR4—, (6) —NR3COO—, (7) —NR3COO—W1—, (8) —NR3CO—CO—, or (9) —NR3CONR4— (wherein R3 and R4 each represents a hydrogen atom, etc., and W1 and W2 each represents an optionally substituted C1-6 alkylene, etc.); and R5 represents an optionally substituted five- or six-membered ring group.
Claims19
A compound represented by the formula
- wherein
- R1 is a C1-6 alkyl group optionally having substituent(s), a C3-8 cycloalkyl group optionally having substituent(s), or a heterocyclic group optionally having substituent(s);
- X is —O— or —NR2— wherein R2 is a hydrogen atom or a C1-6 alkyl group;
- Y is
- wherein ring A is a benzene ring which is optionally further substituted;
- Z is
- (1) —NR3CO—W1—,
- (2) —NR3CO—W1—O—,
- (3) —NR3CO—W1—O—W2—,
- (4) —NR3CO—W1—S—,
- (5) —NR3CO—W1—NR4—,
- (6) —NR3COO—,
- (7) —NR3COO—W1—,
- (8) —NR3CO—CO—,
- (9) —NR3CONR4—,
- (10) —NR3CONR4—W1—, or
- (11) —NR3CONR4—W1—
- wherein R3 and R4 are each independently a hydrogen atom or a C1-6 alkyl group,
- W1 and W2 are each independently a C1-6 alkylene group optionally having substituent(s), a C2-6 alkenylene group optionally having substituent(s), a C2-6 alkynylene group optionally having substituent(s), or a C3-6 cycloalkylene group optionally having substituent(s);
- and
- R5 is a 5- or 6-membered ring group optionally having substituent(s),
- or a salt thereof.
N-{5-[4-fluoro-3-({[2-(trifluoromethyl)phenyl]acetyl}-amino)phenoxy][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide, or a salt thereof.
N-{5-[4-fluoro-3-({[4-(trifluoromethyl)phenyl]acetyl}-amino)phenoxy][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide, or a salt thereof.
N-{5-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]acetyl}-amino)phenoxy][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide, or a salt thereof.
N-{5-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]carbamoyl}-amino)phenoxy][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide, or a salt thereof.
N-{5-[4-fluoro-3-({[6-(trifluoromethyl)pyridin-3-yl]carbamoyl}amino)phenoxy][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide, or a salt thereof.
Dependencies are inferred from the claim text.