Methods for preventing or treating cardiac arrhythmia
AssigneesChanRx Corp., The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsArthur M. Brown, Naresh Chand
Life of this patent
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Abstract
Disclosed are methods of preventing or treating cardiac arrhythmia comprising administering to a mammal in need thereof, such as a human, an effective amount of vanoxerine (GBR 12909) or a pharmaceutically acceptable salt, derivative or metabolite thereof.
Claims14
A method for preventing or treating cardiac arrhythmia comprising administering to a mammal in need thereof an effective amount of vanoxerine or a pharmaceutically acceptable salt, derivative or metabolite thereof.
A method of modulating the activity of an ion channel of mammalian cell, comprising contacting a mammalian cell with an effective amount of vanoxerine, or pharmaceutically acceptable salt, derivative or metabolite thereof.
A method of screening for compounds that bind to IKr or hERG comprising:
- (i) contacting a mammalian cell that stably expresses IKr or hERG with labeled vanoxerine, or a pharmaceutically acceptable salt, derivative or metabolite thereof, to form a labeled binding pair, (ii) contacting said labeled binding pair with a compound of interest;
- and (iii) determining whether said compound of interest displaces said labeled vanoxerine, or said pharmaceutically acceptable salt, derivative or metabolite thereof.
Dependencies are inferred from the claim text.