Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists

A compound of formula II-A:

• or a pharmaceutically acceptable salt thereof, wherein:
• a) R1 is —OR4 or —OCO(C1-C6 alkyl);
• ring A is substituted with q occurrences of RA;
• q is 0, 1, or 2;
• each occurrence of RA is independently halogen, an optionally substituted linear or branched C1-C6alkyl, or an optionally substituted C3-C6cycloalkyl ring;
• each occurrence of R4 is independently hydrogen or an optionally substituted group selected from C1-C6aliphatic or a 3-7-membered saturated, partially unsaturated, or aromatic monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• b) ring B is substituted with r occurrences of —RB;
• r is 0, 1, or 2;
• each occurrence of —RB is independently C1-C3alkyl, or two occurrences of RB, taken together with their intervening atom(s), form an optionally substituted fused or bridged 5 or 6-membered saturated, partially unsaturated, or aromatic ring having 0 heteroatoms;
• c) R2 is -Cy2, or -T-Cy2;
• X is N;
• T, when present, is —CO—, or —CH2—;
• Cy2 is phenyl or naphthyl;
• wherein Cy2 is substituted with 0, 1, or 2 occurrences of —R6a;
• each occurrence of —R6a is independently —Br, —F, —CN, —OCH3, —OCH2CH3, —OCH2CH2CH3, —CF3, —CH3, —CH2CH3, —CH2CH2CH3, —CH(CH3)2, —C(CH3)3, —COOH, —COOCH3, or —COOCH2CH3;
• d) Cy1 is phenyl or naphthyl;
• wherein Cy1 is substituted with 0, 1, or 2 occurrences of —R10a;
• each occurrence of —R10a is independently —Cl, —Br, —F, —NO2, —CN, —OCH3, —OCH2CH3, —OCH2CH2CH3, —CF3, —OCF3, —CH3, —CH2CH3, —CH2CH2CH3, —C(CH3)3, —CH(CH3)2, t-Bu, —NHCOCH3, —NHCONHCH3, —SCH3, —SCH2CH3, —SCH2CH2CH3, —NH2, —NHCH3, —SO2NH2, —COON, —COOCH3, —COOCH2CH3, —NHCH3, —N(CH3)2, —NH(CH2CH3), —N(CH2CH3)2, —OC(CH3)2CO2H, —OCH2CO2H, —C(CH3)2OH, —CONH2, —NHCONH2, —NHCON(CH3)2, or —NHCOOCH3;
• and
• 0 or 1 occurrence of —R10b, J-R10b, or W-J-R10b, and —R10b, J-R10b, or W-J-R10b is morpholinyl, tetrazolyl,
• phenyl, benzyl, —NHCO(phenyl), —NHCO(benzyl), —NH(phenyl), —NHCH2(phenyl), —NH(benzyl), —S(phenyl), —S(benzyl), —O(phenyl), or —O(benzyl), wherein the phenyl and benzyl groups are optionally substituted.