Biaryl compositions and methods for modulating a kinase cascade
AssigneeKinex Pharmaceuticals, LLC
InventorDavid G. Hangauer, JR.
Life of this patent
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Abstract
The invention relates to compounds and methods for modulating one or more components of a kinase cascade. The invention relates to compounds of the formula I: or a pharmaceutically acceptable salt thereof The compounds of the invention are useful for methods of protecting against or treating hearing loss, osteoporosis, cell proliferative disorders, obesity, diabetes, eye disease, stroke, atherosclerosis, neuropathic pain or hepatitis B.
Claims17
A compound according to Formula IA
- or a pharmaceutically acceptable salt thereof, wherein:
- T is a bond;
- Xy is N;
- Xz is CZ;
- Xa is CRa or N;
- Xb is CRb;
- Xc is CRc;
- Xd is CRd;
- Xe is CRe;
- Ra is hydrogen;
- Rb is P,
- wherein
- W is H or (C1, C2, C3, C4, C5, or C6) alkyl;
- V is a bond or —OCH2CH2—;
- P is O-lower (C1, C2, C3, C4, C5, or C6)alkyl-K;
- K is tetrazole;
- Rc and R5 are, independently, hydrogen, (C1, C2, C3, C4, C5, or C6)alkyl or halogen;
- Rd, Re and R4 are hydrogen;
- Z is
- wherein R1, R2, and R3 are, independently, hydrogen or (C1, C2, C3, C4, C5, or C6)alkyl;
- R7 and R11 are selected from hydrogen, (C1, C2, C3, C4, C5, or C6)alkoxy and O-benzyl;
- R8 and R10 are selected from hydrogen and halogen;
- R9 is hydrogen;
- n is 1;
- and m is 1.
A method of treating a disease or disorder selected from lung cancer, colon cancer, precancerous colon lesions, ovarian cancer, breast cancer, epithelial cancer, esophageal cancer, non-small cell lung cancer, pancreatic cancer, psoriases, hearing loss, osteoporosis, cardiovascular disorders, immune system dysfunction, type II diabetes, obesity, transplant rejection, eye diseases, stroke, atherosclerosis, chronic neuropathic pain, and hepatitis B, comprising administering to a subject in need thereof a compound selected from
Dependencies are inferred from the claim text.