Inhibitors of hcv ns5a

The compound of any of the preceding claims wherein

• Rc, Rd, Re and Rf are each independently selected from the group consisting of:
• hydrogen, C1 to C8 alkyl and C1 to C8 heteroalkyl, wherein,
• each hetero atom, if present, is independently N, O or S,
• Rc and Rd are optionally joined to form a 4- to 8-membered heterocycle which is optionally fused to another 3- to 6-membered heterocycle, and
• Re and Rf are optionally joined to form a 4- to 8-membered heterocycle which is optionally fused to another 3- to 6-membered heterocycle.

A compound having formula VI:

• wherein
• each
• is independently a divalent aryl or heteroaryl group which may be polycyclic with varying connective patterns;
• each r is independently 0, 1, 2, 3, or 4;
• each Ra is independently selected from the group consisting of —OH, —CN, —NO2, halogen, C1 to C12 alkyl, C1 to C12 heteroalkyl, cycloalkyl, heterocycle, aryl, heteroaryl, aralkyl, alkoxy, alkoxycarbonyl, alkanoyl, carbamoyl, substituted sulfonyl, sulfonate, sulfonamide and amino;
• A and A′ are independently selected from the group consisting of a single bond, —(CR2)n—O—(CR2)p—, —(CR2)n—N(RN)—(CR2)p—, —(CR2)n—S(O)k—N(RN)—(CR2)p—, —(CR2)n—C(O)—N(RN)—(CR2)p—, —(CR2)n—N(RN)—C(O)—N(RN)—(CR2)p—, —(CR2)n—C(O)—O—(CR2)p—, —(CR2)n—N(RN)—S(O)k—N(RN)—(CR2)p— and —(CR2)n—N(RN)—C(O)—O—(CR2)p— and a heteroaryl group selected from the group consisting of
• wherein:
• X1 is CH2, NH, O or S,
• Y1, Y2 and Z1 are each independently CH or N,
• X2 is NH, O or S,
• V is —CH2—CH2—, —CH═CH—, —N═CH—, (CH2)a—N(RN)—(CH2)b— or —(CH2)a—O—(CH2)b—, wherein a and b are independently 0, 1, 2, or 3 with the proviso that a and b are not both 0,
• optionally includes 1 or 2 nitrogens as heteroatoms on the phenyl residue,
• the carbons of the heteroaryl group are each independently optionally substituted with a substituent selected from the group consisting of —OH, —CN, —NO2, halogen, C1 to C12 alkyl, C1 to C12 heteroalkyl, cycloalkyl, heterocycle, aryl, heteroaryl, aralkyl, alkoxy, alkoxycarbonyl, alkanoyl, carbamoyl, substituted sulfonyl, sulfonate, sulfonamide and amino,
• the nitrogens, if present, of the heteroaryl group are each independently optionally substituted with a substituent selected from the group consisting of —OH, C1 to C12 alkyl, C1 to C12 heteroalkyl, cycloalkyl, heterocycle, aryl, heteroaryl, aralkyl, alkoxy, alkoxycarbonyl, alkanoyl, carbamoyl, substituted sulfonyl, sulfonate and sulfonamide,
• a and b are independently 1, 2, or 3,
• c and d are independently 1 or 2,
• n and p are independently 0, 1, 2 or 3,
• k is 0, 1, or 2,
• each R is independently selected from the group consisting of hydrogen, —OH, —CN, —NO2, halogen, C1 to C12 alkyl, C1 to C12 heteroalkyl, cycloalkyl, heterocycle, aryl, heteroaryl, aralkyl, alkoxy, alkoxycarbonyl, alkanoyl, carbamoyl, substituted sulfonyl, sulfonate, sulfonamide and amino,
• each RN is independently selected from the group consisting of hydrogen, —OH, C1 to C12 alkyl, C1 to C12 heteroalkyl, cycloalkyl, heterocycle, aryl, heteroaryl, aralkyl, alkoxy, alkoxycarbonyl, alkanoyl, carbamoyl, substituted sulfonyl, sulfonate and sulfonamide, and
• wherein for each A and A′, B may be attached to either side of A and A′ so that in the example of A or A′ being
• the A-B-A′ can be any of:
• Rc, Rd, Re and Rf are each independently selected from the group consisting of:
• hydrogen, C1 to C8 alkyl, C1 to C8 heteroalkyl, aralkyl and a 4- to 8-membered ring which may be cycloalkyl, heterocycle, heteroaryl or aryl, wherein,
• each hetero atom, if present, is independently N, O or S,
• each of Rc, Rd, Re and Rf may optionally be substituted by C1 to C8 alkyl, C1 to C8 heteroalkyl, aralkyl, or a 4- to 8-membered ring which may be cycloalkyl, heterocycle, heteroaryl or aryl and wherein each heteroatom, if present, is independently N, O or S,
• Rc and Rd are optionally joined to form a 4- to 8-membered heterocycle which is optionally fused to another 3- to 6-membered heterocycle or heteroaryl ring, and
• Re and Rf are optionally joined to form a 4- to 8-membered heterocycle which is optionally fused to another 3- to 6-membered heterocycle or heteroaryl ring;
• Y and Y′ are each independently carbon or nitrogen;
• and
• Z and Z′ are independently selected from the group consisting of hydrogen, C1 to C8 alkyl, C1 to C8 heteroalkyl, cycloalkyl, heterocycle, aryl, heteroaryl, aralkyl, 1-3 amino acids, —[U—(CR42)t—NR5—(CR42)t]u—U—(CR42)t—NR7—(CR42)t—R8, —U—(CR42)t—R8 and —[U—(CR42)t—NR5—(CR42)t]u—U—(CR42)t—O—(CR42)t—R8, wherein,
• U is selected from the group consisting of —C(O)—, —C(S)— and —S(O)2—,
• each R4, R5 and R7 is independently selected from the group consisting of hydrogen, C1 to C8 alkyl, C1 to C8 heteroalkyl, cycloalkyl, heterocycle, aryl, heteroaryl and aralkyl,
• R8 is selected from the group consisting of hydrogen, C1 to C8 alkyl, C1 to C8 heteroalkyl, cycloalkyl, heterocycle, aryl, heteroaryl, aralkyl, —C(O)—R81, —C(S)—R81, —C(O)—O—R81, —C(O)—N—R812, —S(O)2—R81 and —S(O)2—N—R812, wherein each R81 is independently chosen from the group consisting of hydrogen, C1 to C8 alkyl, C1 to C8 heteroalkyl, cycloalkyl, heterocycle, aryl, heteroaryl and aralkyl,
• optionally, R7 and R8 together form a 4-7 membered ring,
• each t is independently 0, 1, 2, 3, or 4, and
• u is 0, 1, or 2.