Amide compounds, compositions and uses thereof

A compound according formula 2a:

• wherein
• X′ is selected from CR4a and N;
• R1 is selected from substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl;
• each of R2a and R2b is independently selected from hydrogen, C1-C4 alkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, haloalkyl, and halo;
• or R2a and R2b join together to form a cycloalkyl or heterocycloalkyl ring of 3-7 atoms;
• R3 is substituted or unsubstituted 6-10 membered aryl, or substituted or unsubstituted 6-10 membered heteroaryl;
• and when R3 is 6,5 fused bicyclic heteroaryl then R3 is joined to the core group via the 6 membered ring;
• R3 is N containing heterocycloalkyl, unsubstituted or substituted with one or more groups selected from alkyl, halo, haloalkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, dialkylaminoalkyl, alkylsulfonylalkyl, and oxo;
• and the heterocycloalkyl is attached to the core group via the N;
• each R4a, and R4b is independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkythio, substituted or unsubstituted alkoxy, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted alkylarylamino, substituted or unsubstituted arylalkyloxy, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, sulfo, substituted sulfo, substituted sulfonyl, substituted sulfinyl, substituted sulfanyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted arylsulfonyl, azido, substituted or unsubstituted carbamoyl, carboxyl, cyano, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted dialkylamino, halo, heteroaryloxy, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroalkyl, hydroxy, nitro, and thiol;
• and subscript m′ is selected from 0-4;
• and the subscript n2 is 0 or 1;
• or a pharmaceutically acceptable salt, solvate, prodrug, stereoisomer, tautomer or isotopic variant thereof;
• provided that
• a) when n2 is 0, R1 is other than Me;
• or
• b) the compound is other than
• i) 3,5-di(4-fluorophenyl)benzoic acid N-[1-methyl-2-[4-(pyrimidin-2-yl)piperazin-1-yl]ethyl]amide;
• ii) 3,5-di(4-fluorophenyl)benzoic acid N-[1-methyl-2-(4-acetylpiperazin-1-yl)ethyl]amide;
• iii) 3-(3-fluoro-2-pyridinyl)-N-[2-hydroxy-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl]-5-(5-methyl-2-pyridinyl)-benzamide;
• iv) 3-(5-methyl-2-pyridinyl)-5-(1-piperidinyl)-N-[(1S)-1-(1H-1,2,4-triazol-5-yl)ethyl]-benzamide;
• v) N-[(1R)-1-(3-fluoro-2-pyridinyl)ethyl]-3-(5-methyl-2-pyridinyl)-5-(1-piperidinyl)-benzamide;
• vii) 5-(2,4-dioxo-1-imidazolidinyl)-2′-fluoro-4′-methyl-N-(1-methylethyl)-[1,1′-biphenyl]-3-carboxamide;
• viii) N-(3,3-dimethylbutyl)-γ-hydroxy-α-methyl-δ-[[[5-(2-oxo-1-pyrrolidinyl) [1,1′-biphenyl]-3-yl]carbonyl]amino]-,(αR,δS,γS)-benzenehexanamide;
• ix) 2-[[3′-[(2R)-2-[(dimethylamino)carbonyl]-1-pyrrolidinyl]-5′-[[[(1S)-1-[(dimethylamino)methyl]-2-phenylethyl]amino]carbonyl]-2-methoxy[1,1′-biphenyl]-3-yl]methyl]-4-[(1S)-1-hydroxyethyl]-5-(hydroxymethyl)-N-[(1S,2S,3S,5R)-2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]-, (3S,4R,5R)-3-isoxazolidinecarboxamide;
• or
• x) N-(3,3-dimethylbutyl)-γ-hydroxy-α-methyl-δ-[[[5-(2-oxo-1-pyrrolidinyl)[1,1′-biphenyl]-3-yl]carbonyl]amino]-(αR,δS,γS)-benzenehexanamide.