Use of modified pyrimidine compounds to promote stem cell migration and proliferation
AssigneeUniversity of Central Florida Research Foundation, Inc.
InventorsKiminobu Sugaya, Tingyu Qu
Life of this patent
Estimating the term…
Abstract
This invention provides cells and methods for stimulating proliferation and migration of endogenous and exogenous mammalian stem cells in vivo and in vitro. The invention provides reagents and methods for efficiently proliferating mammalian stem cells in an animal in need thereof and producing stem cells that can be re-introduced into an animal in need thereof to alleviate neurological and corporal disorders.
Claims5
A method of increasing cognitive function in a mammal by stimulating proliferation, migration or both proliferation and migration of endogenous mammalian neural stem cells in the cerebral cortex of said mammal , the method comprising administering an effective amount for a pharmaceutically acceptable salt thereof, for an effective period to the mammal,
- wherein R1 to R8 independently represent a hydrogen atom, a lower alkyl group, CH3OCH2CH2—, CH2CONH2, —COCH3, —COC2H5 or —CH2OCOC2H5, and X represents NH, N—CH3, N—C2H5, N-ph, N—COOC2H5, N—SO2CH3, CH2, CHCH3, CHC2H5, —O— or —S— in which ph stands for a phenyl group.
A method of improving vision by stimulating proliferation, migration or both proliferation and migration of endogenous mammalian retinal stem cells in a mammal in need thereof, the method comprising administering an effective amount of a pyrimidine derivative of formula (1) or (2), or a pharmaceutically acceptable salt thereof, for an effective period to the mammal,
- wherein R1 to R8 independently represent a hydrogen atom, a lower alkyl group, CH3OCH2CH2—, CH2CONH2, —COCH3, —COC2H5 or —CH2OCOC2H5, and X represents NH, N—CH3, N—C2H5, N-ph, N—COOC2H5, N—SO2CH3, CH2, CHCH3, CHC2H5, —O— or —S— in which ph stands for a phenyl group.
Dependencies are inferred from the claim text.