Method for the preparation of a crystalline form
AssigneeBoehringer Ingelheim International GmbH
InventorsDirk Weber, Svenja Renner, Tobias Fiedler, Simone Orlich
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Abstract
The invention relates to a method for the preparation for a crystalline form of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene. In addition the invention relates to a crystalline form obtainable by this method, to a pharmaceutical composition and to the use thereof for preparing medicaments.
Claims13
A method for preparing a crystalline form of a compound 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene comprising the following steps:
- (a) dissolving the compound in a mixture of at least two solvents to form a solution wherein the first solvent is selected from the group of solvents consisting of toluene and tetrahydrofuran, and the second solvent is selected from the group of solvents consisting of methanol, ethanol, 1-propanol and 2-propanol, or
- the first solvent is ethanol and the second solvent is selected from the group of solvents consisting of ethylacetate, n-propylacetate and methylethylketone;
- (b) storing the solution to precipitate the crystalline form of the compound out of solution;
- (c) isolating the crystalline form of the compound from the solution.
The crystalline form of a compound 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene having an X-ray powder diffraction pattern that comprises peaks at 18.84, 20.36 and 25.21 degrees 2Θ (±0.1 degrees 2Θ), wherein said X-ray powder diffraction pattern is made using CuKα1 radiation characterized by a purity above 99% as measured by HPLC.
Dependencies are inferred from the claim text.