Plant-derived elastin binding protein ligands and methods of using the same
AssigneesHuman Matrix Sciences, LLC, The Hospital for Sick Children
InventorsFelipe JIMENEZ, Thomas F. MITTS, Aleksander HINEK
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Abstract
The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of GXXPG (SEQ ID NO. 2) containing peptides. The present invention also describes therapeutic compositions containing novel plant derived peptides or peptidomimetics useful in stimulating elastogenensis and capillary dilatation. The therapeutic compositions of the present invention that comprise novel plant derived peptides or peptidomimetics may be combined with other therapeutic agents.
Claims22
A synthetic sextapeptide having a sequence X1-X2-X3-X4-X5-X6 (SEQ ID NO. 3), wherein
- X1 is V or I;
- X2 is G;
- X3 is A or L;
- X4 M or S;
- X5 is P;
- and
- X6 is G.
A synthetic linked sextapeptide having a sequence X1-X2-X3-X4-X5-X6,-X7-X1-X2-X3-X4-X5-X6 (SEQ ID NO. 16) wherein
- X7 is a linking moiety;
- X1 is independently selected from V and I;
- X2 is G;
- X3 is independently selected from A and L;
- X4 is independently selected from M and S;
- X5 is P;
- and
- X6 is G.
A method of stimulating elastogenesis comprising administering a therapeutically effective amount of a composition comprising a synthetic sextapeptide having a sequence X1-X2-X3-X4-X5-X6 (SEQ ID NO. 3), wherein
- X1 is V or I;
- X2 is G;
- X3 is A or L;
- X4 is M or S;
- X5 is P;
- and
- X6 is G.
A composition comprising a synthetic sextapeptide having the sequence IGVAPG (SEQ ID NO. 13).
A composition comprising a synthetic linked sextapeptide selected from the group consisting of VGVAPGAAAAAVGVAPG (SEQ ID NO 10) and IGVAPGAAAAAIGVAPG (SEQ ID NO. 14).
A cosmetic preparation comprising an extract derived from a plant, wherein said extract contains an elastin-like peptide, wherein said elastin-like peptide comprises desmosine.
Dependencies are inferred from the claim text.