Detection of Mutations in a Gene Associated with Resistance to Viral Infection, OAS1
OwnerShawn P. Iadonato, Charles L. Magness +3inventors
InventorsShawn P. Iadonato, Charles L. Magness, Gary Rosenberg, Christina A. Scherer, Thierry Guillaudeux
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Abstract
A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided.
Claims11
1-27. (canceled)
A method of treating viral infection in a mammal comprising administering to a mammal in need of such treatment a composition comprising a polypeptide consisting of the amino acid sequence of SEQ ID NO:48 or an amino acid sequence with at least 95% sequence homology to SEQ ID NO:48.
29-31. (canceled)
39-81. (canceled)
Dependencies are inferred from the claim text.