Antinecrotic activity of alpha 1-antitrypsin
OwnerIlana Nathan, Eli Lewis +1inventors
InventorsIlana Nathan, Eli Lewis, Boris Khalfin
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Abstract
The present invention is related to the use of alpha-1-antitrypsin as an anti-necrotic agent. This invention provides a method for the treatment of tissue necrosis by administration of alpha-1-antitrypsin. This invention further provides methods for prophylactic treatment of tissue necrosis and for inhibition of tissue necrosis in culture by addition of alpha-1-antitrypsin.
Claims24
A method of treating a subject suffering from a disease characterized by tissue necrosis, said method comprising administering to said subject a therapeutically effective amount of alpha-1-antitrypsin or a homologue or variant thereof, wherein said effective amount inhibits said tissue necrosis and said disease is characterized in that affected tissue in said subject is undergoing necrosis.
A method of prophylactically treating a subject at risk for a pathological condition that is precipitated at least in part by tissue necrosis, said method comprising administering to said subject a therapeutically effective amount of alpha-1-antitrypsin such that said effective amount inhibits tissue necrosis in said subject.
A method for inhibiting necrosis in a cell or tissue culture, said method comprising contacting a cell or tissue in culture with an amount of alpha-1-antitrypsin sufficient to inhibit necrosis in said cell or tissue in culture.
A method of preventing pancreatitis in a subject, comprising administering to said subject a therapeutically effective amount of alpha-1-antitrypsin prior to an abdominal surgical procedure in said subject, thereby preventing pancreatitis in a subject.
Dependencies are inferred from the claim text.