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US 2011/0237464 A1Published application
Guided Mode Resonant Filter Biosensor Using a Linear Grating Surface Structure
AssigneeSRU Biosystems, Inc.
InventorsBrian T. Cunningham, Peter Li, Jean Qiu, Homer Pien
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Abstract
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.
Claims17
A biosensor comprising:
- (a) a grating layer comprising a one-dimensional or two-dimensional grating having a first surface, wherein the grating layer is comprised of a low refractive index material;
- (b) an interfacial layer on the first surface of the grating layer;
- (c) a high refractive index material layer on a surface of the interfacial layer opposite of the grating layer;
- and
- (d) one or more specific binding substances immobilized on a surface of the high refractive index material layer opposite of the interfacial layer;
- wherein, when the biosensor is illuminated a resonant grating effect is produced on the reflected radiation spectrum.
3 more elements
Dependencies are inferred from the claim text.