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US 2011/0237458 A1Published application
Drug discovery method
AssigneeKeddem Bioscience Ltd.
InventorDror OFER
Life of this patent
Estimating the term…
Abstract
A method of obtaining information about a chemically active area of a target molecule, for example for drug discovery, comprising: providing a set of substantially rigid chemical gauges; reacting said target with a plurality of gauges of said set of gauges; assaying a binding of said gauges with said target to obtain a plurality of assay results; and analyzing said assay results to obtain information about said chemically active area.
Claims20
A set of substantially rigid chemical gauges, each of said gauges being a compound comprising at least one set of three binding points in a substantially rigid triangular configuration,
- such that for a triangle space which defines all possible 3-point pharmacophores defined by a triplet of distances that form a triangle, each distance being in a range of 2-12 angstrom, and by a triplet of chemical binding point types for the triangle vertices, each chemical binding point type being selected from the group consisting of acid, base, hydrophobic, hydrogen-bond donor, hydrogen-bond acceptor, and aromatic:
- for each point in 50% of said triangle space, said set of gauges comprises at least six gauges with a substantially rigid triangular configuration of binding points capable of chemically binding to a 3-point pharmacophore corresponding to said point.
Dependencies are inferred from the claim text.