Method and system of particle-coupled phage epitope
AssigneeArmune Biosciences, Inc.
InventorsJeanne OHRNBERGER, Stephen A. Spindler
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Abstract
The present disclosure provides compositions and methods for using phage epitopes to profile the immune response. The phage epitopes can be used to detect one or more antibodies from a sample. Furthermore, the present disclosure provides methods and compositions for detecting a cancer based on the detection of one or more antibodies. In one embodiment, the antibody is an autoantibody.
Claims28
An antibody detecting complex comprising:
- a) a polypeptide probe, wherein said probe is capable of being specifically bound by an antibody, and said probe is present on a phage;
- and,
- b) a particle, wherein said particle is coupled to said phage.
An antibody profiling panel comprising a plurality of antibody detecting complexes, wherein each of said antibody detecting complex comprises:
- a) a polypeptide probe, wherein said probe is capable of being specifically bound by an antibody, and said probe is present on a phage;
- and,
- b) a particle, wherein said particle is coupled to said phage.
A method for detecting a disease or condition comprising:
- a) contacting a sample from a subject with an antibody detecting complex, wherein said complex comprises:
- i) a polypeptide probe, wherein said probe is capable of being specifically bound by an antibody, and said probe is present on a phage, and
- ii) a particle, wherein said particle is coupled to said phage;
- b) detecting a presence or level of an antibody bound to said antibody detecting complex;
- and
- c) detecting said disease or condition based on said presence or level of said antibody.
A method for detecting a disease or condition comprising:
- a) contacting a sample from a subject with an antibody profiling panel, wherein said panel comprises a plurality of antibody detecting complexes, wherein each of said antibody detecting complex comprises:
- i) a polypeptide probe, wherein said probe is capable of being specifically bound by an antibody, and said probe is present on a phage, and,
- ii) a particle, wherein said particle is coupled to said phage;
- b) detecting a presence or level of a plurality of antibodies bound to said plurality of antibody detecting complexes;
- and
- c) detecting said disease or condition based on said presence or level of said plurality of antibodies.
Dependencies are inferred from the claim text.