Methods and systems of using exosomes for determining phenotypes
AssigneeCaris Life Sciences Luxembourg Holdings
InventorsMichael R. Klass, Christine KUSLICH, George Poste
Life of this patent
Estimating the term…
Abstract
Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.
Claims28
A method of assessing a cancer in a subject comprising:
- identifying a bio-signature of an exosome population isolated from said subject, comprising:
- a) determining the levels of:
- (i) CD9, CD63, CD81 biomarker protein or a combination thereof, of said exosome population;
- (ii) one or more cell-specific biomarker of said exosome population;
- and (iii) one or more additional biomarker from said exosome population that is indicative of cancer;
- and b) comparing said levels of said biomarkers from said exosome population to a reference, wherein elevated levels as compared to said reference indicate that said subject may be predisposed to or afflicted with cancer, thereby assessing said cancer.
A method of assessing a disease or disorder in a subject comprising:
- a) determining the amount of exosomes present in a sample isolated from a subject and b) comparing said amount to a reference, wherein elevated levels as compared to said reference indicate that said subject may be predisposed to or afflicted with cancer, thereby assessing said cancer.
Dependencies are inferred from the claim text.