Method of detecting a specific nucleophile and surface acoustic wave sensor for detecting the specific nucleophile
AssigneesSamsung Electronics Co., Ltd., Chung-Ang University Industry-Academy Cooperation Foundation
InventorsSoo Suk LEE, Yeol Ho LEE, Min Su HAN
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Abstract
Provided herein is a method of detecting the presence of a specific nucleophile, which uses a material Y degraded by nucleophilic substitution of reacting with a specific nucleophile X, and a material Z selectively binding to a material Y′ produced by the degradation. According to the method, the nucleophile X can be easily analyzed according to the bonding between the materials Y′ and Z.
Claims14
A method of selectively detecting the presence or absence of a specific nucleophile in a sample, the method comprising:
- contacting the sample with a receptor comprising a material Y which is selectively reactive with the specific nucleophile X, to form a material Y′;
- contacting the material Y′ with a material Z which selectively binds to the material Y′ to bond the material the material Y′ to the material Z;
- and
- observing whether the bonding between the material Y′ and the material Z occurs or not, to selectively detect the presence or the absence of the specific nucleophile X.
A surface acoustic wave sensor for selectively detecting a specific nucleophile, the surface acoustic wave sensor comprising:
- a piezoelectric substrate;
- a first and a second inter-digitated transducer disposed on the substrate;
- and
- a reaction layer disposed on the piezoelectric substrate and covering the first and the second inter-digitated transducers, and comprising a receptor selectively reactive with a specific nucleophile X to be detected,
- wherein the receptor is selectively reactive with the nucleophile to form a thiol, and
- wherein a metal nanoparticle selectively binds to the thiol.
A sensor for detecting a cyanide ion, the sensor comprising:
- a reaction unit having a receptor reactive with a cyanide ion,
- wherein the receptor comprises a thioester convertable into an alkanethiol by nucleophilic substitution with the cyanide ion, and the alkanethiol is reactive with an adenosine-5′-triphosphate stabilized gold nanoparticle to change a color of the gold nanoparticle or a mass of the receptor.
Dependencies are inferred from the claim text.