Antioxidant protection of a chemical sensor
AssigneeGlumetrics, Inc.
InventorsJEFF T. SURI, RITCHIE A. WESSLING, THOMAS A. PEYSER, SOYA GAMSEY, ERIC E. PATTERSON
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Abstract
Analyte sensors having antioxidant protection are disclosed. By combining antioxidant and/or scavenger agents into polymer matrices that contain sensor moieties, the sensor moieties are protected from reactive oxygen species. Also disclosed are methods of making analyte sensors and methods of inhibiting oxidative degradation of sensing components in hydrated, polymerized analyte sensor systems.
Claims28
An analyte sensor, comprising an equilibrium fluorescence indicator system and at least one antioxidant, wherein each of the equilibrium fluorescence indicator system and the at least one antioxidant is immobilized within a polymer matrix.
An analyte sensor, comprising an equilibrium fluorescence indicator system immobilized within an insoluble polymer matrix and a porous metal coating surrounding said insoluble polymer matrix.
An analyte sensor, comprising:
- an optical fiber with proximal and distal ends;
- a chemical indicator system capable of generating an emission light signal in response to an excitation light signal, wherein the intensity of the emission light signal is related to the analyte concentration, and wherein the chemical indicator system is immobilized within a gap in the optical fiber by a polymer matrix;
- a selectively permeable membrane disposed over the gap;
- and
- a external coating that contains one or more antioxidant,
- wherein the sensor is sized for deployment within a blood vessel.
An analyte sensor comprising an equilibrium fluorescence indicator system and at least one antioxidant, wherein the equilibrium fluorescence indicator is immobilized within a polymer matrix and the at least one antioxidant is covalently bound to a semi-permeable membrane that surrounds the polymer matrix.
Dependencies are inferred from the claim text.