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US 2011/0236967 A1Published application
Promiscuous her-2/neu cd4 t cell epitopes
AssigneeDendreon Corporation
InventorsJami B. Wollan, Lori A. Jones
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Abstract
The present invention relates to the discovery of novel T cell epitopes of the human HER-2/Neu protein that is promiscuous for at least 25 different HLA-DR alleles. The invention also relates to compositions that contain one of the novel epitopes or a fusion peptide of such a epitope and a heterologous polypeptide. Further disclosed herein is the use of the epitopes or their fusion peptides, and compositions containing the epitopes or their fusion peptides.
Claims9
An isolated nucleic acid comprising a polynucleotide sequence encoding a peptide consisting of:
- (a) 12 to 15 contiguous amino acids of residues 3-17 of SEQ ID NO:1;
- or (b) 16 to 18 contiguous amino acids of SEQ ID NO:l.
Dependencies are inferred from the claim text.