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US 2011/0236957 A1Published application
Nanoparticle Labeling Reagents and Methods of Use
AssigneeThe Regents of the University of California
InventorKevin C. Weng
Life of this patent
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Abstract
Compositions and methods for labeling biological targets using a conjugate of a luminescent component and a targeting molecule attached to a nanoparticle core structure are described. The labeling conjugates offer high intensity and low background, and are ideal for histology and pathology.
Claims24
A method for labeling a biological target, comprising:
- providing a biological target for labeling;
- and
- incubating the biological target with a single-reagent labeling composition comprising
- (i) a nanoparticle core structure
- (ii) a targeting moleculing specific for the biologic target, and
- (iii) at least one luminescent component;
- wherein said incubating achieves labeling of the biological target with the single-reagent labeling composition.
4 more elements
A composition for labeling a biological target comprising:
- a single labeling reagent comprising a nanoparticle core structure having a plurality of binding sites for multiplex attachment of at least one targeting molecule, and at least one luminescent component having one or more preselected wavelengths.
A composition for labeling a biological target, comprising:
- a single labeling regent comprising a nanoparticle core structure, at least one targeting molecule, and at least one luminescent component having one or more preselected wavelengths.
Dependencies are inferred from the claim text.