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US 2011/0236952 A1Published application
Novel substrates of o6-alkylguanine-dna alkyltransferase and mutants thereof
AssigneeCIS Bio International
InventorsEmmanuel Bourrier, Michel Laget, Laurent Lamarque, Norbet Tinel, Eric Trinquet, Hervé Bazin
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Abstract
The invention relates to compounds of formula (I′): in which A, L2, M and B are as defined in the description. These compounds are substrates of O6-alkylguanine-DNA alkyltransferase and mutants
Claims15
A compound of formula (I′):
- in which:
- B represents a group of formula (II′) or (III′) below:
- in which the dotted lines represent the bonds with the oxygen of the formula (I′),
- R1 is chosen from:
- H, NH2, an OH group or an oxo group,
- R2 is chosen from:
- NH2, OH or oxo,
- R3 is chosen from:
- H or a CH3 group;
- L2 is a linker;
- M is a molecule of interest or a reactive group;
- A is chosen from the following divalent groups:
9 more elements
Dependencies are inferred from the claim text.