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US 2011/0236912 A1Published application
Systems and methods for characterizing lupus erythematosus
AssigneeRenovar Incorporated
InventorsGanesh Vasudevan, Huaizhong Hu, Stuart Knechtle
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Abstract
The present invention provides systems and methods for characterizing biological markers in the urine of systemic lupus erythematosus (SLE) subjects. In particular, the present invention relates to the detection of cytokines and chemokines in urine of SLE subjects for determining nephritic disease states and kidney damage in SLE subjects and the efficacy of agents and interventions used to treat lupus nephritis.
Claims18
A method of detecting a disorder of the kidney associated with lupus, comprising:
- a) providing;
- i) a urine sample from a subject, wherein said subject is suspected of having lupus nephritis;
- and
- ii) reagents for quantification of one or more compounds from the list comprising MCP-1, IGFBP-2, osteoprotegerin, and uPAR;
- and
- b) quantifying the amount of said compounds in said urine sample using said reagents.
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