Lgr5 modulators in the treatment of alopecia
AssigneeGalderma Research & Development
InventorSandrine Rethore
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Abstract
An in vitro method of screening for candidate compounds for the preventive or curative treatment of alopecia, which comprises determining the ability of a compound to modulate the expression or the activity of the LGR5 receptor is described. The use of modulators of the expression or of the activity of this receptor for treating alopecia is also described. In addition, methods for the diagnosis or prognosis, in vitro, of this disease are described.
Claims17
An in vitro method of screening for candidate compounds for treatment of alopecia, the method comprising determining the ability of a compound to modulate the expression or the activity of LGR5 or the expression of its gene or the activity of at least one of its promoters.
A cosmetic for aesthetic treatment of the scalp, the cosmetic comprising an effective amount of a LGR5 receptor modulator.
An in vitro method for the diagnosis or the monitoring of the development of alopecia in an individual, the method comprising comparing the expression or of-the activity of the LGR5 protein, or the expression of its gene or the activity of at least one of its promoters, in a biological sample from an individual, with a biological sample from a control individual.
An in vitro method for the determination of the predisposition of an individual to developing alopecia, the method comprising comparing the expression or the activity of the LGR5 protein, or the expression of its gene or the activity of at least one of its promoters, in a biological sample from an individual, compared with a biological sample from a control individual.
Dependencies are inferred from the claim text.