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US 2011/0236878 A1Published application
Rapid Characterization of Proteins in Complex Biological Fluids
OwnerIvan Correiainventor
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Abstract
Disclosed herein are compositions and methods for the rapid screening of candidate protein therapeutics. In particular, the instant invention provides compositions and methods for assaying the behavior of candidate protein therapeutics in complex biological fluids and for identifying those candidate protein therapeutics exhibiting desirable pharmacokinetic properties in such fluids.
Claims14
A method for analyzing a physiochemical property of a candidate protein therapeutic, comprising:
- (a) labeling said candidate protein therapeutic;
- (b) exposing said labeled candidate protein therapeutic to a complex biological fluid;
- (b) obtaining a sample of said complex biological fluid comprising said labeled candidate protein therapeutic;
- (c) separating the components of said sample in a microfluidic device based on a physical attribute of the candidate protein therapeutic;
- and
- (d) detecting said label to determine a physiochemical property of said candidate protein therapeutic in the separated sample.
3 more elements
Dependencies are inferred from the claim text.