Method for formation of renal tubules
OwnerDaniele Zink, Jackie Y. Ying +4inventors
InventorsDaniele Zink, Jackie Y. Ying, Huishi Zhang, Farah Tasnim, Huishi Zhang, Farah Tasnim
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Abstract
There is provided a method of making a renal tubule. The method comprises seeding renal tubule cells onto a solid surface; culturing the renal tubule cells in a liquid growth medium to form a monolayer on the solid surface; and continuing culturing the renal tubule cells to form a tubule.
Claims20
A method of making a renal tubule, the method comprising:
- seeding renal tubule cells onto a solid surface;
- culturing the renal tubule cells in a liquid growth medium to form a monolayer on the solid surface;
- and
- continuing culturing the renal tubule cells to form a tubule, the resulting tubule having an unbranched or minimally branched morphology, a length of from about 0.1 mm and an interior lumen surrounded mostly by differentiated epithelial cells.
An in vitro generated renal tubule formed on a solid surface and having an unbranched or minimally branched morphology, a length of from about 0.1 mm and an interior lumen surrounded mostly by differentiated epithelial cells.
Dependencies are inferred from the claim text.