Injectable dual delivery allograph bone/polymer composite for treatment of open fractures
AssigneeVanderbilt University
InventorsScott A. Guelcher, Bing Li, Andrea E. Hafeman, Joseph C. Wenke, Kate V. Brown
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Abstract
A biodegradable polyurethane scaffold, comprising at least one polyisocyante, polyisocyanate prepolymer, or both, at least one polyester polyol, at least one catalyst, wherein the density of said scaffold is from about 50 to about 250 kg m-3 and the porosity of the scaffold is greater than about 70 (vol %) and at least 50% of the pores are interconnected with another pore, and wherein the scaffold incorporates at least one biologically active component in powder form.
Claims32
A biodegradable polyurethane scaffold, comprising
- at least one polyisocyante, polyisocyanate prepolymer, or both;
- at least one polyester polyol;
- at least one catalyst;
- wherein the density of said scaffold is from about 50 to about 250 kg m-3 and the porosity of the scaffold is greater than about 70 (vol %) and at least 50% of the pores are interconnected with another pore;
- and
- wherein the scaffold incorporates at least one biologically active component in powder form.
A composition that comprises:
- at least one polyisocyante, polyisocyanate prepolymer, or both;
- at least one polyester polyol;
- at least one catalyst;
- and
- at least one biologically active component in powder form.
A method of delivering a biologically active agent to a wound site comprising:
- providing a composition that comprises at least one polyisocyante, polyisocyanate prepolymer, or both;
- at least one polyester polyol;
- at least one catalyst;
- and at least one biologically active component in powder form;
- and
- contacting the composition with a wound site.
Dependencies are inferred from the claim text.