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US 2011/0236497 A1Published application
Compositions and Methods for Improved Retention of a Pharmaceutical Composition at a Local Administration Site
AssigneeEvonik Corporation
InventorsThomas R. Tice, Kevin W. Burton
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Abstract
Disclosed herein are compositions comprising cross-linkers for cross-linking a retention vehicle polymer. The compositions are particularly useful for local administration of a bioactive agent, wherein prolonged or extended availability of the bioactive agent at the site of administration is desired. Also disclosed are methods of delivering the compositions to a subject.
Claims21
A composition comprising:
- a retention vehicle polymer;
- and a controlled release cross-linking agent for cross-linking the retention vehicle polymer in situ in a subject.
A method for delivering a bioactive agent to a subject, comprising:
- injecting into the subject a composition comprising:
- a biodegradable polymeric microparticle comprising a bioactive agent encapsulated therein;
- a retention vehicle polymer;
- and a controlled release cross-linking agent for cross-linking the retention vehicle polymer in situ in the subject.controlled release cross-linking agent
1 more element
A biodegradable polymeric microparticle comprising a ligand that binds to a joint tissue.
Dependencies are inferred from the claim text.