Anti-cancer nanoparticle compositions and methods of use
AssigneeBoard of Trustees of the University of Arkansas
InventorsAnna Radominska-Pandya, Alexandru S. Biris
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Abstract
The present invention encompasses a composition capable of delivering and expressing a nucleic acid encoding UDP-Glucuronosyltransferases, p53 or a combination thereof into a cell, and methods for treating tumors.
Claims20
A composition comprising at least one nucleic acid attached to a nanoparticle, wherein the nucleic acid comprises an anti-cancer nucleic acid, and wherein the anti-cancer nucleic acid is selected from the group consisting of UDP-glucuronosyltransferase and p53.
A method of treating tumor cells, the method comprising contacting a tumor cell with a composition comprising at least one nucleic acid attached to a nanoparticle, such that the anti-cancer nucleic acid is expressed within the tumor cell, and wherein the nucleic acid encodes an anti-cancer nucleic acid, and wherein the anti-cancer nucleic acid is selected from the group consisting of UDP-glucuronosyltransferase and p53.
Dependencies are inferred from the claim text.