Vaccine adjuvant combinations
AssigneeNovartis AG
InventorsMichele Pallaoro, Derek O'Hagan, Rino Rappuoli
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Abstract
An immunological adjuvant comprises an oil-in-water emulsion, an immunostimulatory oligonucleotide and a polycationic polymer, wherein the oligonucleotide and the polymer ideally associate with each other to form a complex. The adjuvant can be combined with immunogens for preparing vaccines.
Claims15
An immunological adjuvant comprising an oil-in-water emulsion, an immunostimulatory oligonucleotide and a polycationic polymer.
An immunological adjuvant comprising an oil-in-water emulsion and an adsorptive particulate adjuvant, wherein the average diameter of particles in the adsorptive particulate adjuvant is greater than the average diameter of oil droplets in the emulsion, and wherein the adsorptive particulate adjuvant is a complex of an immunostimulatory oligonucleotide and a polycationic polymer.
An immunological adjuvant comprising an oil-in-water emulsion and an immunostimulatory oligonucleotide, wherein the immunostimulatory oligonucleotide includes at least one CpI motif.
An immunological adjuvant comprising an oil-in-water emulsion and an adsorptive particulate adjuvant, wherein the average diameter of particles in the adsorptive particulate adjuvant and the average diameter of oil droplets in the emulsion are both less than 250 nm.
Dependencies are inferred from the claim text.