Pharmaceutical Compositions of Selective Factor Xa Inhibitors for Oral Administration
AssigneeMerrion Research III Limited
InventorsThomas W. Leonard, David C. Coughlan, Allan Cullen
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Abstract
The present invention provides pharmaceutical compositions for oral administration comprising a therapeutically effective amount of a selective factor Xa inhibitor or a pharmaceutically acceptable salt thereof and an enhancer, wherein the enhancer is a medium chain fatty acid or a salt, ester, ether, or derivative of a medium chain fatty acid and has a carbon chain length of from about 4 to about 20 carbon atoms. The present invention also provides a method for obtaining a reproducible bioavailability of selective factor Xa inhibitor in an object after oral administration comprising orally administering a pharmaceutical composition as described above.
Claims37
A pharmaceutical composition for oral administration, comprising a therapeutically effective amount of a selective factor Xa inhibitor or a pharmaceutically acceptable salt thereof and an enhancer, wherein the enhancer is a medium chain fatty acid or a salt, ester, ether, or derivative of a medium chain fatty acid and has a carbon chain length of from about 4 to about 20 carbon atoms.
17-22. (canceled)
31-44. (canceled)
46-47. (canceled)
49-50. (canceled)
A pharmaceutical composition comprising a selective factor Xa inhibitor or a pharmaceutically acceptable salt thereof, wherein said pharmaceutical composition provides a bioavailability of the selective factor Xa inhibitor or a pharmaceutically acceptable salt thereof of at least about 10% when orally administered to a human subject.
52-53. (canceled)
Dependencies are inferred from the claim text.