Methods for stimulating chondrogenesis utilizing a potassium channel inhibitor
OwnerT. Michael Underhillinventor
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Abstract
The invention is directed to a method for stimulating chondrogenesis comprising administering to a subject in need thereof a composition comprising a therapeutically effective amount of a potassium channel inhibitor.
Claims27
A method for stimulating chondrogenesis or for preventing chondrocyte hypertrophy or maturation or for treating a chondrogenic disease, the method comprising administering to a subject in need thereof a composition comprising a therapeutically effective amount of a potassium channel inhibitor.
2-3. (canceled)
A method for treating or repairing a cartilage defect or for treating, ameliorating or repairing a skeletal defect, a large segmental skeletal gap, or a non-union fracture arising from trauma or surgery, the method comprising administering to a subject in need thereof a composition comprising a therapeutically effective amount of a potassium channel inhibitor.
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A method for the ex vivo engineering of chondrocytes comprising:
- (a) culturing a population of precursor cells of chondrocyte lineage with a composition comprising a potassium channel inhibitor for a time sufficient to stimulate chondrogenesis;
- and
- (b) implanting the cells from (a) into a desired site in a subject.
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20-22. (canceled)
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30-43. (canceled)
Dependencies are inferred from the claim text.