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US 2011/0236445 A1Published application
Mouthwash in the form of a stable suspension comprising microspheres that incorporate an active ingredient
AssigneePharmafilm S.R.L.
InventorsFrancesco Cilurzo, Paola Minghetti
Life of this patent
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Abstract
The present invention relates to a mouthwash including microspheres that incorporate an active ingredient, wherein the microspheres are obtained directly in situ in the aqueous phase of the mouthwash by cross-linking. These microspheres do not tend to aggregate and the mouthwash appears in the form of a homogenous and stable suspension even after prolonged storage.
Claims10
A mouthwash comprising microspheres incorporating an active ingredient wherein the microspheres are obtained in situ by adding drops of size smaller than 700 μm of an aqueous polymer dispersion (A) containing:
- a) polyacrylic acid, optionally cross-linked and optionally in the form of a salt with an alkali metal;
- and
- b) an alkali metal alginate
- to an aqueous solution (B) containing a pharmaceutically acceptable organic or inorganic salt of an alkaline earth metal able to cross-link the alginate, wherein the active ingredient (c) is contained either in polymer dispersion (A) or in aqueous solution (B) or in both dispersion (A) and solution (B).
1 more element
Dependencies are inferred from the claim text.