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US 2011/0236418 A1Published application
Materials and Methods for Improved Vaccination
AssigneeIsis Innovation Limited
InventorsMichael J. Palmowski, Luciene Lopes, Yasuhiro Ikeda, Vincenzo Cerundolo, Mary K. Collins
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Abstract
The invention relates to materials and methods for improved vaccination strategies and in particular to the use of lentivirus comprising nucleic acid encoding an antigen, or antigen presenting cells transduced with such lentivirus, to stimulate immune responses against the encoded antigen, in heterologous prime-boost vaccination regimes.
Claims23
1-45. (canceled)
A method of stimulating an immune response to an antigen in an individual by a prime-boost immunisation protocol, the method comprising the steps of
- (i) administering to the individual a priming composition encoding or containing an antigen to prime said immune response;
- (ii) administering to the individual a boosting composition encoding or containing said antigen to boost the primed immune response;
- wherein said priming and boosting compositions comprise an infectious, replication-deficient lentivirus comprising nucleic acid encoding said antigen, or an antigen presenting cell transduced in vitro with a lentiviral vector comprising nucleic acid encoding said antigen, and wherein the lentivirus or the lentiviral vector of said boosting composition is immunologically different to that of the priming composition.
A pharmaceutical composition comprising
- (i) a priming composition encoding or containing an antigen to prime said immune response;
- and
- (ii) a boosting composition encoding or containing said antigen to boost the primed immune response;
- wherein said priming and boosting compositions comprise an infectious, replication-deficient lentivirus comprising nucleic acid encoding said antigen, or an antigen presenting cell transduced in vitro with a lentiviral vector comprising nucleic acid encoding said antigen, and wherein the lentivirus or the lentiviral vector of said boosting composition is immunologically different to that of the priming composition.
1 more element
Dependencies are inferred from the claim text.