Compositions and methods for modulating lymphocyte activity
AssigneeWashington University
InventorsKenneth M. Murphy, Theresa L. Murphy
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Abstract
The invention derives from the identification of HVEM as the native ligand for BTLA. The invention provides compositions and methods for modulating BTLA-HVEM interactions and BTLA and HVEM activity, which are useful for modulating immune responses. Agonists and antagonists of the BTLA-HVEM interaction are provided, and methods of treating a variety of conditions through the modulation of immune responses are provided.
Claims8
A method of modulating an immune response to an antigen, comprising administering a BTLA-HVEM agonist.
A method of treating asthma, cancer, inflammatory disease, or autoimmune disease, the method comprising administering to a patient in need of such treatment a therapeutically effective amount of a BTLA-HVEM agonist.
Dependencies are inferred from the claim text.