Compositions and methods for prophylactic and therapeutic treatment of infection
AssigneeBiosynexus Incorporated
InventorsJames J. Mond, Irwin Scher, John F. Kokai-Kun
Life of this patent
Estimating the term…
Abstract
This invention is directed to compositions and methods for treating (e.g., prophylactically and/or therapeutically) infection in a preterm infant. In particular, the invention provides anti-lipoteichoic acid (LTA) antibody compositions and methods of administering the same to a preterm infant (e.g., a low birth weight preterm infant (e.g., a very low birth weight preterm infant)) under conditions to establish anti-LTA antibody serum concentrations effective to kill and/or prevent growth of bacteria (e.g., Staphylococci). Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine) and research applications.
Claims24
A method of treating a preterm low birth weight infant comprising providing a preterm low birth weight infant, wherein the infant has, is suspected of having or is at risk for bacterial infection and administering a composition comprising an anti-LTA antibody to the infant under conditions such that the infant obtains a serum concentration of the anti-LTA antibody that is greater than the serum concentration of anti-LTA antibody needed to provide protection from or killing of bacteria in a full term infant.
An anti-LTA antibody composition, wherein the composition is formulated for intravenous infusion of 100 milligrams per kilogram weight of a preterm low birth weight infant.
Dependencies are inferred from the claim text.