Method for obtaining an excipient-free antibody solution
OwnerHanns-Christian Mahler, Robert Muellerinventors
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Abstract
The present invention relates to a method of ultra- and dialfiltrating an antibody solution containing at least one solute in addition to the antibody, which comprises diafiltrating the antibody solution with a solvent and bringing said mixture into contact with a semi-permeable membrane so as to allow the at least one solute present in the antibody solution and having a molecular weight lower than the molecular weight cut-off of the membrane to pass through the membrane, whilst retaining the antibody so that a modified antibody solution is obtained that only contains the antibody and the solvent.
Claims11
A method of ultra- and diafiltrating an antibody solution containing at least one solute in addition to the antibody, which comprises diafiltering the antibody solution with a solvent and bringing said mixture into contact with a semi-permeable membrane so as to allow the at least one solute present in the antibody solution and having a molecular weight lower than the molecular weight cut-off of the membrane to pass through the membrane, whilst retaining the antibody so that an antibody solution is obtained that only contains the antibody and the solvent.
The method and purified antibodies substantially as hereinbefore described, especially with reference to the foregoing examples.
Dependencies are inferred from the claim text.